Some mutations do not affect an organism's phenotype. Other mutations cause minor changes, and still others cause major changes. Which is most likely to cause a major change in an organism's phenotype?
A) a substitution of a single base
B) an insertion of three consecutive bases
C) the deletion of one arm of a chromosome
D) a deletion of two bases at the end of a gene
Answer: C) the deletion of one arm of a chromosome
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