A patient has been diagnosed with a fungal infection and is to be treated with itraconazole (Sporanox). Prior to administration, the nurse notes that the patient is taking carbamazepine (Tegretol) for a seizure disorder
Based on this medication regime, which of the following will be true regarding the medications? A) The serum level of carbamazepine will be increased.
B) The patient's carbamazepine should be discontinued.
C) The patient's antiseizure medication should be changed.
D) The patient will require a higher dosage of itraconazole (Sporanox).
D
Feedback:
Drugs that induce drug-metabolizing enzymes (e.g., carbamazepine, phenytoin, rifampin) decrease serum concentrations of itraconazole. The serum level of carbamazepine will not need to be increased. The carbamazepine should not be discontinued or changed.
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