The process by which a medication passing through the liver may be partially or completely inactivate many medications is known as:
a. First-pass effect
b. Prodrug effect
c. Protein reservoir binding
d. Plasma binding effect
a
Rationale: a. Correct.
b. A prodrug is an inactive precursor of a drug prior to conversion to an active metabolite.
c. Protein reservoir binding occurs when a portion of a drug is bound to proteins but may be released for us at a later time.
d. Plasma binding occurs with proteins as described above in answer c.
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A) Food and Drug Administration B) Dental Museum C) National Library of Medicine D) National Library of Dentistry E) All of the above