First-generation cephalosporins are the most effective of this class of antibiotics against:
1. Protozoans.
2. Gram-negative bacteria.
3. Rickettsia.
4. Gram-positive bacteria.
Correct Answer: 4
Rationale 1: First-generation cephalosporins are more effective against another type of organism.
Rationale 2: First-generation cephalosporins are more effective against another type of organism.
Rationale 3: First-generation cephalosporins are more effective against another type of organism.
Rationale 4: First-generation cephalosporins are the most effective cephalosporins against gram-positive bacteria.
Global Rationale: First-generation cephalosporins contain a beta-lactam ring; bacteria that produce beta lactamase are usually resistant to these drugs. They are the most effective cephalosporins against gram-positive bacteria, including staphylococci and streptococci and are sometimes the preferred drugs for these organisms. First-generation cephalosporins have only moderate activity against gram-negative bacteria.
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