Order: Hycamtin (topotecan HCl) 1.5 mg/mIV daily for five days, repeat every 21 days. The label on the vial reads 4 mg, and the manufacturer's directions state: "Reconstitute each 4 mg with 4 mL of sterile water
Withdraw the dose and further dilute in 50 mL D5W and infuse over 30 minutes." Calculate the rate of flow in milliliters per hour for a patient who weighs 92 kg and is 183 cm tall. 1. 106 mL/h
2. 114 mL/h
3. 100 mL/h
4. 87.5 mL/h
1
Global Rationale: 2.16 m2 × 1.5 = 3.24 mg = 3.24 mL; 53 ml/0.5 h = 106 mL/h.
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