Topical diphenhydramine (Benadryl) is available OTC to treat itching. Patients or parents should be instructed regarding the use of topical diphenhydramine that:
1. For maximum effectiveness in treating itching, combine topical with oral diphenhydramine.
2. Topical diphenhydramine is the treatment of choice in treating poison ivy or poison oak.
3. Topical diphenhydramine should not be used in children younger than age 2 years.
4. When applying topical diphenhydramine, apply the cream liberally to all areas that itch.
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