A research study is conducted using newborn screening samples analyzed and stored over two years at a state health department. Study results are inconsistent and erratic. What are the likely reasons for this variability?
Note: Credit will be given only if all correct choices and no incorrect choices are selected.
Standard Text: Select all that apply.
1. Differences in the way samples were originally collected
2. Degradation of the samples over time
3. Contamination from the original analysis
4. Inexperience using newborn screening samples
5. High numbers of conditions screened in these samples
2,3
Rationale 1: The samples are all used for the same newborn screen and would have been collected using the same methodology.
Rationale 2: Depending on storage methods, the samples may have degraded significantly in a two-year period.
Rationale 3: As the samples have already been handled and analyzed, they may have been contaminated.
Rationale 4: The study design would outline the procedure for analyzing the samples, so inexperience should not be a factor.
Rationale 5: The study is likely looking at only one aspect of the sample. The number of tests that could be done is not a factor.
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