Which instruction is most appropriate for a client who is prescribed pancrelipase (Cotazym)?
1. Increase dosing with a large meal.
2. Decrease fluid intake.
3. Take the medication at least 2 hours prior to meals.
4. Take the medication with meals.
Correct Answer: 4
Rationale 1: Increase dosing with a large meal is incorrect because overtreatment can cause nausea, vomiting, and diarrhea.
Rationale 2: Decrease fluid intake is incorrect because this is not necessary with this medication.
Rationale 3: Decrease fluid intake is incorrect because this is not necessary with this medication.
Rationale 4: Dosing is individualized to the degree of pancreatic insufficiency in each patient. Administration of the drug is timed to coincide with meals so that the enzymes are available when food reaches the duodenum.
Global Rationale: Dosing is individualized to the degree of pancreatic insufficiency in each patient. Administration of the drug is timed to coincide with meals so that the enzymes are available when food reaches the duodenum. Increase dosing with a large meal is incorrect because overtreatment can cause nausea, vomiting, and diarrhea. Decrease fluid intake is incorrect because this is not necessary with this medication. Decrease fluid intake is incorrect because this is not necessary with this medication.
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