A primary care NP is preparing to prescribe a drug and notes that the drug has nonlinear kinetics. The NP should:
a. monitor frequently for desired and adverse effects.
b. administer a much higher initial dose as a loading dose.
c. monitor creatinine clearance at baseline and periodically.
d. administer the drug via a route that avoids the first-pass effect.
A
Drugs with nonlinear kinetics are not eliminated based on dose or concentration of the drug, and these drugs have a narrow therapeutic window and must be monitored closely for desired effects and toxicity.
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