Considering that the digestive system is a major route of infection in most human cases of brucellosis, an investigator hypothesizes that the production of urease by the organism plays a key role as a virulence factor as well as in the organism's survival in the upper digestive tract. Indicate all of the following explanations that accurately describe the mechanism of action of the enzyme urease. Select all that apply.
a. As a result of urea hydrolysis, there is an increase in pH due to the production of ammonia.
b. As a result of urea hydrolysis, there is a decrease in pH due to the production of ammonia.
c. The increased production of ammonia by urea hydrolysis serves to neutralize stomach acid, promoting survival of the organism.
d. The increased production of ammonia by urea hydrolysis serves to increase stomach acid, promoting survival of the organism.
Answer:
a. As a result of urea hydrolysis, there is an increase in pH due to the production of ammonia.
c. The increased production of ammonia by urea hydrolysis serves to neutralize stomach acid, promoting survival of the organism.
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of the ____ contract(s).
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