The nurse is caring for a group of clients who are receiving chemotherapy. The nurse is preparing to administer the medications. Which medications does the nurse correctly identify as alkylating agents? (Select all that apply.)

Question

Note: Credit will be given only if all correct choices and no incorrect choices are selected.

1. Cisplatin (Platinol)
2. Cyclophosphamide (Cytoxan)
3. Chlorambucil (Leukeran)
4. Estramustine (Emcyt)
5. Interferon alfa-2 (Roferon A)

Answer 1

Correct Answer: 1, 2, 3, 4

Rationale 1: Cisplatin (Platinol) is an alkylating agent.
Rationale 2: Cyclophosphamide (Cytoxan) is an alkylating agent.
Rationale 3: Chlorambucil (Leukeran) is an alkylating agent.
Rationale 4: Estramustine (Emcyt) is an alkylating agent.
Rationale 5: Interferon alfa-2 (Roferon A) is a biologic response modifier used to treat hairy cell leukemia and Kaposi's sarcoma.

Global Rationale: Cisplatin (Platinol), cyclophosphamide (Cytoxan), chlorambucil (Leukeran), and estramustine (Emcyt) are all alkylating agents. Interferon alfa-2 (Roferon A) is a biologic response modifier used to treat hairy cell leukemia and Kaposi's sarcoma.