A patient is admitted to the hospital with severe dehydration and also has decreased albumin levels. What effect will the patient's current status have if a prescribed dose of phenytoin (Dilantin) is administered?
A) Potentially toxic serum level
B) Reduced serum level
C) Increased seizure activity
D) Thromboembolism
A
Feedback:
Phenytoin is highly bound to plasma proteins and only a fraction is not bound to albumin; hypoalbuminemia will result in toxic serum levels of phenytoin. A reduced serum level of phenytoin will not be seen with hypoalbuminemia. The patient will not suffer from increased seizure activity. The patient will not suffer from thromboembolism.
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