What is the most appropriate explanation as to why dipivefrin hydrochloride (Propine) effectively decreases intraocular pressure?
1. The exact mechanism is not fully understood.
2. It decreases the formation of aqueous humor.
3. It reduces plasma volume very quickly.
4. It converts to epinephrine and increases outflow of aqueous humor.
Correct Answer: 4
Rationale 1: The exact mechanism is not fully understood is incorrect. Beta blocking agents decrease the formation of aqueous humor, but the exact mechanism is not fully understood.
Rationale 2: It decreases the formation of aqueous humor is incorrect. Beta blocking agents decrease the formation of aqueous humor, but the exact mechanism is not fully understood.
Rationale 3: It reduces plasma volume very quickly is incorrect because osmotic diuretics reduce plasma volume very quickly.
Rationale 4: Sympathomimetic drugs such as Propine and Ipinal convert to epinephrine and produce mydriasis, which is the increased outflow of aqueous humor and the subsequent fall of IOP.
Global Rationale: Sympathomimetic drugs such as Propine and Ipinal convert to epinephrine and produce mydriasis, which is the increased outflow of aqueous humor and the subsequent fall of IOP. The exact mechanism is not fully understood is incorrect. Beta blocking agents decrease the formation of aqueous humor, but the exact mechanism is not fully understood. Decreasing the formation of aqueous humor is incorrect. Beta blocking agents decrease the formation of aqueous humor, but the exact mechanism is not fully understood. Reducing plasma volume very quickly is incorrect because osmotic diuretics reduce plasma volume very quickly.
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