What is characteristic of antithyroid drugs that act on the thyroid gland? (Select all that apply.)
a. They are a physiologic hormone replacement.
b. They block synthesis of T3 and T4 in the thyroid gland.
c. They destroy T3 and T4.
d. Immediate improvement is observed.
e. They may be used before subtotal thyroidectomy.
ANS: B, E
Antithyroid drugs act by blocking the synthesis of T3 and T4. They are prescribed long term for patients with hyperthyroidism and may be used for short-term treatment before subtotal thyroidectomy. Antithyroid drugs are not related to synthetic or physiologic hormone replacement. Antithyroid drugs act by blocking the synthesis of, not destroying, T3 and T4. There is a latency period of a few days to 3 weeks before symptoms improve.
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