In the whole-genome shotgun method, the genome is fragmented and individual fragments are sequenced. How is the
order of the nucleotides determined for the original intact chromosome?
a. The fragmentation is done in a systematic way such that the physical arrangement of fragments is readily
apparent.
b. The random fragmentation produces overlapping sequencesthat can be aligned and assembled to generate the
original intact DNA molecule.
c. We supplement our information with data from a different technique to determine the final chromosome
arrangement.
d. DNA hybridization assays are conducted to determine the physical arrangement of the genes on the
chromosome.
e. After sequencing, the fragments are labeled and used as probes in a microarray.
ANSWER: b
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