A transmembrane protein has 1000 amino acids. The fifth amino acid is found on the external surface of the cell membrane. It interacts with the aqueous environment outside the cell
Amino acids 25 and 205 are covalently bonded to each other and are required to give the protein its three-dimensional shape. Amino acid 554 is found on the outer surface of the protein, but it is deep in the interior of the membrane. Amino acid 979 is found on the external surface of the protein, where it forms a weak ionic bond with a chloride ion. Can you identify each of the numbered amino acids by structural group and name? Please note that there may be more than one specific amino acid possible in some cases.
Amino acids:
5
25
205
554
979
What will be an ideal response?
Answer: 5: polar, charged or uncharged (hydrophilic) amino acid; any amino acid in this group
25: polar, uncharged (hydrophilic) amino acid; cysteine
205: polar, uncharged (hydrophilic) amino acid; cysteine
554: nonpolar (hydrophobic) amino acid; any amino acid in this group
979: polar, charged (hydrophilic) amino acid; any positively charged amino acid in this group (Lys, Arg, or His)
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