What would be the best approach for an artificial selection regime for a microbiome?
A. Sequence genomes of all microbial strains, analyze genes, transfer best candidates to host and assess phenotype.
B. Use antibiotics to destroy microbiome, compare axenic phenotype vs. normal host, then transfer microbiome back to axenic hosts.
C. Assess host phenotype, collect microbiome of the best, and transfer to more host individuals for reselection.
D. Determine which strain is most common in healthiest hosts, then transfer this strain to axenic hosts for phenotype assessment.
Answer: C
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