Primates, as well as dogs, sheep, and horses, have died of central nervous system (CNS) infections with which organism?

a. N. fowleri
b. Acanthamoeba spp.
c. Toxoplasma gondii
d. Balamuthia mandrillaris


D
B. mandrillaris is uncommon and was thought to be a harmless soil organism, with no relevance for infecting mammals. However, since B. mandrillaris was first recognized at the San Diego Wild Animal Park when a gibbon died of meningoencephalitis, a number of primates, as well as dogs, sheep, and horses, have died of CNS infection caused by this organism. Approximately 100 cases of human amebic encephalitis worldwide have been identified with approximately one-half of the cases diagnosed in the United States. Death can occur from a week to several months after the onset of symptoms. Patients eventually die with a massive CNS infection.

Biology & Microbiology

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