What effect do metabolic acidosis and aldosterone have in common?
a. They both result in renal loss of K+.
b. There is a loss of HCO3– and Cl– in the renal tubules.
c. There is retention of CO2 and Cl–.
d. They both cause renal retention of HCO3–.
ANS: A
Renal excretion of K+ is controlled by aldosterone levels. Aldosterone inhibits the enzyme re-sponsible for K+ transport in the distal renal tubular cells of the kidney. Metabolic acidosis also inhibits the transport system.
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