What is the role of sex hormone binding globulin? How does SHBG play a role in PCOS?
What will be an ideal response?
Sex hormone binding globulin binds to estradiol and testosterone in the blood, allowing only a small amount to circulate as free molecules (unbound). Unbound hormones are biologically active; hormones bound to SHBG are not active. The bioavailability (activity) of estradiol and testosterone are influenced by the levels of SHBG. PCOS is primarily a syndrome of increased testosterone activity in females. Decreased levels of SHBG cause free testosterone levels to be higher and thus more bioactive, resulting in virilization in females.
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A) 7 B) 9 C) 11 D) 13
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