What is the main reason a patient with Parkinson disease cannot be treated with dopamine?

A. Acetylcholine is the main neurotransmitter that is deficient.
B. Injecting dopamine only makes the substantia nigra down-regulate its own production of dopamine.
C. Dopamine is highly addictive, creating a dependence in the patient that is worse than Parkinson disease.
D. Dopamine cannot cross the blood-brain barrier, and it has too many systemic side effects.
E. Dopamine is a protein that is digested in the stomach before it can enter a person's circulation.


D

Anatomy & Physiology

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