The nurse correctly states that which function is not characteristic of the parietal cells?
1. Secretion of intrinsic factor
2. Microbial control
3. Secretion of hydrochloric acid
4. Secretion of pepsinogen
Correct Answer: 4
Rationale 1: Parietal cells secrete intrinsic factor.
Rationale 2: Secretions from parietal cells kill microbes that have been ingested.
Rationale 3: Parietal cells secrete hydrochloric acid.
Rationale 4: Chief cells, not parietal cells, secrete the enzyme pepsinogen.
Global Rationale: Parietal cells secrete gastric (hydrochloric) acid in the stomach, which provides a strongly acidic environment that promotes the conversion of pepsinogen to pepsin, helps to break down food, and kills microbes that may have been ingested. Parietal cells also secrete intrinsic factor, which is essential for the absorption of vitamin B12. Pepsinogen is secreted by chief cells.
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