Computer programs that search for ORFs tend to overestimate the number of functional genes in a genome

One method to validate that a potential gene is functional is to see if the same gene is present in two related species, such as mice and humans. A more stringent criterion is that the shared gene is present in a syntenic region of the chromosome. What is a syntenic region?
What will be an ideal response?


Ans: Although there are a lot of chromosomal rearrangements that shuffle the location of homologous genes among related species, genes that are functionally homologous tend to be located sandwiched between other homologous genes, because of genetic linkage. This relationship is called synteny.

Biology & Microbiology

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