The nurse is caring for a client with Graves disease. What concept related to the client's condition does the nurse recognize as true?
A) Autoantibodies against TSH stimulates thyroxine production.
B) It occurs in hemolytic disease of the newborn due to ABO or Rh incompatibility.
C) Antibodies to acetylcholine receptors cause decreased neuromuscular function.
D) It is characterized by the vascular rejection of organ transplantation.
A) Autoantibodies against TSH stimulates thyroxine production.
Explanation: A) In Graves disease, an autoantibody is directed against thyroid-stimulating hormone (TSH) receptors on thyroid cells, which stimulates thyroxine production, leading to hyperthyroidism.
B) Complement- and antibody receptor-mediated phagocytosis occurs with mismatched blood transfusion reactions, with hemolytic disease of the newborn due to ABO or Rh incompatibility, or with certain drug reactions.
C) In myasthenia gravis, autoantibodies to acetylcholine receptors on the neuromuscular end-plates either block the action of acetylcholine or mediate internalization or destruction of receptors, causing decreased neuromuscular function.
D) Complement- and antibody receptor-mediated inflammation is responsible for the tissue injury seen in glomerulonephritis and vascular rejection in organ transplantation.
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