Which of the following laboratory tests relates most directly with the impaired drug elimination that is expected in neonates?
A) C-reactive protein level
B) Creatine kinase
C) Serum albumin level
D) Glomerular filtration rate
D
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Excretion of most drugs occurs via the kidneys, and elimination in the urine follows. Young children have immature kidneys, a reduced glomerular filtration rate, and slower renal clearance. Neonates are especially prone to increased levels of drugs that are eliminated primarily by the kidneys. CK, albumin, and C-reactive protein levels do not directly relate to this physiological characteristic.
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