A 59-year-old male patient has a long history of heavy alcohol use and was diagnosed with liver cirrhosis several months earlier. The patient's medical history includes numerous other health problems, including angina
When considering the use of nifedipine in the management of this patient's angina, what consideration should the nurse be aware of? A) The patient is likely to experience an increased effect of the medication.
B) This patient will require a higher dose than a patient without this medical history.
C) Nifedipine is contraindicated because it is highly hepatotoxic.
D) The patient's increased albumin levels will negate the therapeutic effect.
A
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In patients with cirrhosis, bioavailability of oral drugs is greatly increased and metabolism (of both oral and parenteral drugs) is greatly decreased. Both of these effects increase plasma levels of drug from a given dose (essentially an overdose).
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