Which of the following best explains how the phenomenon of "tolerance" develops with use of psychoactive drugs over time?
A. Psychoactive drugs can up-regulate receptors for endogenous neurotransmitters.
B. Psychoactive drugs can inhibit production of endogenous neurotransmitters.
C. Psychoactive drugs often produce euphoria.
D. Psychoactive drugs can alter blood flow to the brain.
E. Psychoactive drugs can cross the blood-brain barrier.
Answer: B
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