In Leber's disease (LHON), degeneration of the optic nerve results in blindness due to a defect in NADH dehydrogenase affecting electron transport

If this is due to a mutation in a mitochondrial gene, which combination of the following effects would you expect to see when doing a pedigree analysis of a family with LHON? i. variable expressivity ii. incomplete penetrance iii. progressive blindness over time iv. maternal inheritance v. diminished muscle mass A) i and ii only
B) ii and iii only
C) iii and iv only
D) i, ii, iii, and v only
E) i, ii, iii, and iv only


E

Biology & Microbiology

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