The nurse is providing teaching to a client who will be discharged on isoniazide (INH). Which of the following statements made by the client indicates a need for further medication instruction?
1. "I will take the INH ½ hour after eating breakfast.".
2. "I will make sure I tell all my health care providers that I am taking INH.".
3. "Tuna fish is one of my favorite foods. I will hate having to give it up.".
4. "I will make sure I get my laboratory tests drawn to monitor my liver function.".
"I will take the INH ½ hour after eating breakfast.".
Rationale: INH should be taken 1 hour before meals or on an empty stomach because food interferes with the absorption of the drug. Clients should advise all health care providers that they are taking the medication to avoid drug−drug interactions. Clients should avoid foods containing tyramine and/or histamine, such as tuna, aged cheese, red wine, and soy sauce. Consumption of these foods can lead to experiencing headaches, flushing, or palpitations. Because of the risk of hepatotoxicity, the client should have baseline and monthly evaluations of liver function while on INH.
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