A young adolescent experiences infrequent migraine episodes. What pharmacologic intervention is most likely to be prescribed?
a. Opioid
b. Lorazepam
c. Ergotamine
d. Sumatriptan
ANS: D
Sumatriptan is a serotonin agonist at specific vascular serotonin receptor sites and causes vasoconstriction in large intracranial arteries. Opioids are used infrequently because they rarely work on the mechanism of pain. Lorazepam is a benzodiazepine that acts as an anxiolytic and sedative. It is not indicated for treatment of migraine episodes. Ergotamine, an ?-adrenergic blocker, is used for adult vascular headaches, but it is not used in adolescents because of the side effects.
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