Describe the process of mRNA splicing

What will be an ideal response?


ANSWER: First, snRNPs bind with sequences at the intron-exon junctions. Additional snRNPs are
recruited to form a larger complex that loops out the intron and brings the exons close
together; the active spliceosome has now formed. The active spliceosome then cuts the 5¢
end of the intron, and the intron loops back to bond with itself at its 3¢ end. The spliceosome
then cuts the intron at its 3¢ end and joins together the exons that were on either side of the
intron. The intron is released and later degraded. Meanwhile, the spliceosome disassembles
as the snRNPs are released. When all introns are removed and all exons joined together, the
mRNA is finished and ready for translation.

Biology & Microbiology

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