A student is learning about the process of hematopoiesis and how it is affected by leukemia. Which information does the student discover? (Select all that apply.)
A.
Blast cells multiply faster than mature cells.
B.
Leukemia disrupts normal hematopoiesis.
C.
Lymphoid cells differentiate into B and T cells.
D.
Myeloid cells crowd out normal cells in bone marrow.
E.
Pancytopenia occurs from proliferation of mast cells.
ANS: A, B, C
Blast, or immature, cells have an increased rate of proliferation and multiply at the expense of normal cells. Leukemia does disrupt normal hematopoiesis (production and development of blood cells). Lymphoid cells differentiate into B and T cells. Myeloid cells differentiate into red blood cells, monocytes, granulocytes, and platelets; they do not reproduce and crowd out "normal" cells in the marrow. Pancytopenia occurs when large numbers of blast cells reproduce and crowd out normal marrow components.
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