The nurse and a graduate nurse are reviewing an order for penicillin G (Benzylpenicillin). The nurse is discussing the pharmacokinetics of penicillin G with the graduate nurse
Which statement by the graduate nurse best demonstrates understanding of the pharmacokinetics of penicillin G? a. "Penicillin G is absorbed well when administered enterally and parenterally."
b. "Excretion by the kidneys is subject to the first-pass effect and the cytochrome p-450 system."
c. "Inflammation increases the distribution of penicillin G into the joints and cere-brospinal fluid."
d. "Penicillins generally are bacteriostatic but seldom have bactericidal effects."
C
In the presence of inflammation, penetration of penicillin G into the meninges, joint fluids, and the eye is increased.
Penicillin G is not administered enterally.
Excretion by the kidneys is not subject to the first-pass effect.
Penicillins generally are bactericidal, not bacteriostatic.
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