Explain the role of major histocompatibility complex (MHC) molecules and human leukocyte antigen (HLA) genes in organ transplant and rejection
What will be an ideal response?
Compatibility between organ donor and organ recipient is determined through a process that screens the antigens most likely to cause rejection—those associated with MHC molecules, which are encoded on genes called human leukocyte antigen (HLA) genes. A donor individual who has a high percentage of HLA similarity to the recipient is said to be a match. Exact HLA matches are rare and most likely to be found within families.
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