Discuss the membrane permeabilities of major ions and how they contribute to the overall resting membrane potential of neurons.
What will be an ideal response?
The average resting membrane potential is -70 mV. It is primarily determined by the concentration gradient of K+ and the membrane permeabilities of K+, Na+, and Cl-. The equilibrium potential for K+ predicted by the Nernst equation is -90 mV. The resting membrane potential is more permeable to K than Na. However, because the cell's
resting potential is more positive than -90mV there must be another contributing ion, and it is the Na+ leak channels that allow positive Na+ ions into the cell which cause the resting potential to be slightly more positive.
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