What is NF\kappaB and what is its role in mediating signals through TLRs?
What will be an ideal response?
NFkappaB is a transcription factor, and some TLRs signal through an intracellular pathway that involves the activation of NFkappaB. In the absence of stimulation of the TLR, NFkappaB is found in an inactive form in the cytoplasm. Signaling through the TLR results in a phosphorylation cascade that converts NFkappaB to its active form, which is then able to translocate into the nucleus and direct the transcription of specific genes that promote the cell's response to the infection.
You might also like to view...
Mandatory retirement at age 72 has left Devon in a prolonged depression, and his doctor suggests an antidepressant. Would imipramine be a good choice for him?
A) No. Imipramine has significant anticholinergic action and is inappropriate. B) Possibly, but it depends on what other medications Devon is taking. C) Yes. Imipramine is safe and effective for elderly individuals. D) Yes, but only if psychotherapy does not help Devon.
A device that amplifies sound to provide more precise perception and interpretation of words communicated to the individual with a hearing deficit is called a(n) ___________ ___________
Fill in the blank(s) with correct word
Which structure(s) is/are located between the vaginal orifice and the anus??
A) symphysis pubis B) perineum C) urethral orifice D) fimbriae
Nausea and vomiting may also occur if a victim has had too much alcohol to drink or has motion sickness
Indicate whether the statement is true or false.