Describe the relationship between PEEP and hepatic perfusion.
What will be an ideal response?
The rate of hepatic blood flow is inversely related to the level of PEEP. In one study, the hepatic blood flow decreased 3%, 12%, and 32% at PEEP of 10, 15, and 20 cm H2O, respectively. The decrease in hepatic blood flow is solely caused by a reduction in cardiac output as a result of PEEP. This inference is made because the ratio of hepatic blood flow to cardiac output remains unchanged at 15% during mechanical ventilation without PEEP.
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