The client who has sickle cell trait has a sister with sickle cell disease and a husband with neither the disease nor the trait. She asks her nurse what her children's chances are of having sickle cell disease
What is the nurse's best response? A. "Because you have the trait and your husband does not, only your daughters can have sickle cell disease."
B. "Because you have the trait and your husband does not, none of your children will have the disease, but each child will have a 50% risk for having the trait."
C. "Because your sister actually has sickle cell disease, the risk for your children having sickle cell disease is 50% with each pregnancy."
D. "Because you are a woman, your daughters will each have a 50% risk for having the disease and all of your sons will be carriers of the trait."
B
Sickle cell disease is an autosomal recessive disease. Thus, there are no gender differences or influences in having the disease. Because the disease is recessive, a person needs two mutated gene alleles (homozygous) to have the disease and only one mutated gene allele (heterozygous) to have the trait. This client's husband does not have the disease or the trait and can only contribute a normal hemoglobin gene allele to each child. The client has one abnormal gene allele and has a 50% risk of passing it on to her children with each pregnancy.
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