An important study of HD conducted by A. Yamamoto demonstrated that turning off the HTT gene early in the progression of the disease results in the aggregates being degraded and prevention of the disease. Explain how Yamamoto designed his experiment
What will be an ideal response?
Yamamoto cloned the mHTT gene behind an inducible promoter that responded to doxycycline. When the mice were fed water containing doxycycline, the mHTT gene was turned on and disease progression commenced. When doxycycline was removed from the water, the mHTT gene was turned off and disease progression halted. Yamamoto monitored the aggregates of mHTT and determined that if the gene expression was arrested early enough, the disease state could be reversed by normal cellular functions.
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When comparing DNA sequences of similar genes for proteins in related species, you see that some of the sequences are longer in one species compared to the other
Which of the following would most likely represent the extra number of bases that you would see? A. 5 B. 7 C. 17 D. 21 E. 25
A mutation in a gene that results in a defective protein product is known as a ____ mutation
Fill in the blank with the appropriate word.
Which photoreceptor cell type is present at high concentration in the fovea?
A. amacrine cells B. cone cells C. bipolar cells D. rod cells
Competent cells are those used in studies of conjugation
Indicate whether the statement is true or false