A client presents to the physician's office with complaints of worsening hypothyroidism symptoms
When questioned about medication changes, the client tells the nurse that she has recently started taking an antidepressant prescribed by another physician. Which of the following antidepressants can decrease the effectiveness of levothyroxine?
A) Amitriptyline (Elavil)
B) Quetiapine (Seroquel)
C) Sertraline (Zoloft)
D) Fluoxetine (Prozac)
E) Topiramate (Topamax)
Ans: C, D
Feedback:
Selective serotonin reuptake inhibitors (SSRIs), like sertraline (Zoloft) and fluoxetine (Prozac), can decrease the effectiveness of levothyroxine, leading to the reappearance of hypothyroidism symptoms in clients previously controlled on a dose of levothyroxine.
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