Explain why an organ transplant made between a donor of blood group AB and a recipient of blood group O will always be rejected, even if it is perfectly HLA-matched and the recipient has been given immunosuppressant drugs. What is this type of rejection c
What will be an ideal response?
The organ would be rejected immediately by the process of hyperacute rejection as a result of the presence in the recipient's blood of preformed antibodies against the A and B blood group antigens present on the tissues of the graft. Such antibodies are made early in life as a result of exposure to common bacteria that carry surface carbohydrates similar to those on human cells. A person of blood group O would have made antibodies against bacterial ‘A' and
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