The Janus kinase (JAK) mutation is seen in more than 90% of cases of what disease?
a. Chronic myelogenous leukemia
b. Primary myelofibrosis
c. Plasma cell myeloma
d. Polycythemia vera
ANS: D
The diagnosis of polycythemia vera requires the presence of two major criteria and one minor criteria, or it requires the first major criteria and two minor criteria. The JAK mutation is the second of the major criteria.
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Fill in the blank(s) with the appropriate word(s).