In addition to nitric oxide, which of the following inhalational agents have been approved by the U.S. Food and Drug Administration for the treatment of pulmonary hypertension?
1. Treprostenil
2. Epoprostenol
3. Iloprost
4. Alprostadil
a. 2 only
b. 1 and 3 only
c. 1, 2, 3, and 4
d. 2 and 4 only
ANS: B
The use of nitric oxide gas to treat neonates with persistent pulmonary hypertension is approved by the FDA and is discussed in detail in Chapter 41. In addition to this medical gas, inhaled medications are being tested and used to treat pulmonary hypertension. Several such agents are being studied, including epoprostenol (Flolan) and alprostadil (Prostin VR Pediatric); however, only two, iloprost and treprostenil, are approved by the FDA for widespread use.
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