Monospecific Coombs sera indicates that a patient's red cells have complement coating them. Which of the following red cell morphology would be more likely?
a. Spherocytes
b. Schistocytes
c. Acanthocytes
d. Agglutination
ANS: D
When only complement is present on the membrane, giving a positive direct antiglobulin test using monospecific Coombs sera, a cold agglutinin is most likely present. Agglutination of red blood cells (RBCs) would be seen on the blood provided it is at room temperature.
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