An in vitro preparation of the small intestine is studied. The scientist removes all sodium from the apical (lumen) side. How will this affect the uptake of glucose and fructose? What if all of the sodium is removed from the basolateral (interstitial fluid) side? How will this affect the uptake of glucose and fructose?
What will be an ideal response?
Answer: Since glucose is transported by secondary active transport along with sodium from the lumen on the SGLT transporter, a complete lack of sodium on the luminal side will inhibit glucose uptake. Fructose uptake will not be inhibited as it is absorbed by the GLUT transporter. Sodium on the basolateral side is not critical for the function of the epithelium, so there will be no effect on glucose or fructose reabsorption.
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