Which medication is usually tried first when a child is diagnosed with juvenile idiopathic arthritis (JIA)?
a. Aspirin
b. Corticosteroids
c. Cytotoxic drugs such as methotrexate
d. Nonsteroidal antiinflammatory drugs (NSAIDs)
ANS: D
NSAIDs are the first drugs used in JIA. Naproxen, ibuprofen, and tolmetin are approved for use in children. Aspirin, once the drug of choice, has been replaced by the NSAIDs because they have fewer side effects and easier administration schedules. Corticosteroids are used for life-threatening complications, incapacitating arthritis, and uveitis. Methotrexate is a second-line therapy for JIA.
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