Explain how X inactivation can result in female mosaicism and give examples
What will be an ideal response?
Female mammals are constructed of two different cell types. Some cells express alleles from the father's X chromosome and some cells express alleles from the mother's X chromosome. Early in embryonic development, one X chromosome in each cell will be inactivated. The inactivation will occur randomly. If a visible trait is linked to an inactivated X chromosome, any cells derived from the original inactivated cell will not display the trait. The pattern of coat color in some mice and in some cats, and the patches of affected and unaffected skin on a woman with anhidrotic ectodermal dysplasia represent groups of cells descended from a single cell in which the inactivation event occurred.
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