Imagine that a friend asks you what you have heard about St. John's wort because he is considering using it to alleviate his depression. Which of the following is probably the safest conclusion you can draw?
a. Many people who have reported improvements with St. John's wort, but the effects are typically mild and improvements may depend on the quality of the brand.
b. St. John's wort is superior to prescription antidepressant medications.
c. Your friend may as well take a placebo: Scientific evidence does not support the conclusion that St. John's wort reduces symptoms of depression.
d. St. John's wort is superior to cognitive-behavioral therapies.
Answer: C
Rationale: St. John's wort was no more effective than the placebo.
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