A mother asks the nurse how acetaminophen works. What statement best describes the therapeutic action of acetaminophen?
A) Acetaminophen (Tylenol) works by blocking the increase of interleukin-1.
B) Acetaminophen reacts with free-floating tumor necrosis (TNF) factor released by active leukocytes.
C) Acetaminophen acts directly on the hypothalamus to cause vasodilation and sweating.
D) Acetaminophen is taken up by macrophages, thus inhibiting phagocytosis and release of lysosomal enzymes.
C
Feedback:
Acetaminophen acts on the hypothalamus to cause vasodilation and sweating to reduce fever. The mechanism of action as an analgesic is not understood. Anakinra (Kineret) blocks the increased interleukin-1, which is responsible for the degradation of cartilage in rheumatoid arthritis. Etanercept (Enbrel) reacts with free-floating TNF released by active leukocytes in autoimmune inflammatory disease to prevent the damage caused by TNF. Gold compounds are taken up by macrophages, which, in turn, inhibits phagocytosis and releases lysosomal enzymes, which causes damage associated with inflammation.
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