Discuss appendicitis and why appendectomies are sometimes necessary.
What will be an ideal response?
Appendicitis generally follows an erosion of the epithelial lining of the vermiform appendix. Several factors may
be responsible for the initial ulceration––notably, bacterial or viral pathogens. Bacteria that normally inhabit the
lumen of the large intestine then cross the epithelium and enter the underlying tissues. Inflammation occurs, and
the opening between the vermiform appendix and the rest of the intestinal tract may become constricted. Mucous
secretion and pus formation accelerate, and the organ becomes increasingly distended. Eventually, the swollen and
inflamed appendix may rupture, or perforate. If it does, bacteria will be released into the warm, dark, moist confines
of the peritoneal space, where they can cause a life-threatening peritonitis. The most effective treatment for
appendicitis is the surgical removal of the organ, a procedure known as an appendectomy.
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